Boston is one of the world’s most concentrated hubs of academic medicine and biomedical research, home to Massachusetts General Hospital, Brigham and Women’s Hospital, Boston Medical Center, New England Baptist Hospital, Harvard Medical School, and Boston University School of Medicine. The regenerative medicine market in Greater Boston reflects this academic depth, with providers who combine elite clinical training at Harvard, Columbia, and the Hospital for Special Surgery with published research in orthobiologics, platelet-rich plasma therapy, and tissue engineering. Patients across Boston, Waltham, Wellesley, and Framingham have access to board-certified orthopedic surgeons, physiatrists with fellowship training in sports medicine, and anesthesiology-based pain management specialists offering autologous bone marrow concentrate, platelet-rich plasma, and non-surgical regenerative orthopedic treatments. The providers listed below represent established practices with verified addresses, documented treatment offerings, and publicly available contact information.
This directory is for informational purposes only. It does not constitute medical advice, endorsement, or recommendation. Inclusion in this directory does not imply certification or quality rating. Always consult a qualified healthcare provider before pursuing any treatment.
Quick Guide by Condition
If you are looking for a provider based on your specific concern, this overview may help narrow your search:
Orthopedic joint preservation with regenerative options: Boston Joint Preservation (Dr. Kai Mithoefer) and Boston Medical Center Orthopedics (Dr. Xinning Li) are board-certified orthopedic surgeons offering stem cell and PRP therapies alongside surgical joint preservation. Dr. Mithoefer trained in the Harvard Orthopedic Residency Program and at the Hospital for Special Surgery. Dr. Li completed fellowships at both the Hospital for Special Surgery and Harvard Medical School.
Physiatry-based orthobiologics: Boston Sports and Biologics (Dr. Walter Sussman) is led by the co-author of The Atlas of Interventional Orthopedics and a Board Member of the Interventional Orthobiologic Foundation, offering comprehensive ultrasound-guided regenerative orthopedic procedures.
Academic regenerative medicine program: The Mass General Brigham Regenerative Sports Medicine Program (Dr. Joanne Borg Stein) is directed by a Harvard Medical School Associate Professor and one of the nation’s leading researchers in platelet-rich plasma therapy for degenerative disease and sports injury.
1. Boston Joint Preservation
Boston Joint Preservation is a multi-location practice led by Dr. Kai Mithoefer, a board-certified orthopedic surgeon internationally recognized for joint preservation surgery, regenerative orthopedics, and sports medicine. Dr. Mithoefer received his medical training in Germany before completing the Harvard Orthopedic Residency Program, then completed a fellowship in Orthopedic Trauma at Massachusetts General Hospital and a fellowship in Sports Medicine and Shoulder Surgery at the Hospital for Special Surgery in New York. He is board-certified in both orthopedic surgery and orthopedic sports medicine and has been recognized as a Top Doctor by both Castle Connolly and Boston Magazine continuously since 2019 through 2025. The practice offers stem cell and platelet-rich plasma therapies alongside surgical joint preservation, including an innovative procedure called Intraosseous Bioplasty, which combines surgical core decompression with the patient’s own stem cells and growth factors to encourage bone remodeling and cartilage preservation.
Address: 71 Border Road, Waltham, MA 02451
Phone: (781) 890-2133
Website: https://www.bostonjointpreservation.com
Key Personnel:
- Dr. Kai Mithoefer, MD, Founder, double board-certified in Orthopedic Surgery and Orthopedic Sports Medicine, Harvard Orthopedic Residency Program, MGH Orthopedic Trauma fellowship, Hospital for Special Surgery Sports Medicine and Shoulder Surgery fellowship, Castle Connolly and Boston Magazine Top Doctor 2019-2025
Services Offered:
- Stem cell therapy (bone marrow and growth factor concentrate)
- Platelet-Rich Plasma (PRP) therapy
- Intraosseous Bioplasty (bone marrow stem cells combined with surgical core decompression)
- Orthopedic joint preservation surgery (when indicated)
- Regenerative sports medicine consultation
Conditions Treated: Knee and hip arthritis, shoulder injuries, cartilage damage, bone marrow lesions, sports injuries, ACL and ligament injuries, tendon conditions, degenerative joint disease
2. Boston Sports and Biologics
Boston Sports and Biologics is a Wellesley physiatry and regenerative medicine practice led by Dr. Walter Sussman, a dual board-certified physiatrist and sports medicine specialist who is one of the national leaders in orthobiologic procedures. Dr. Sussman received his Doctor of Osteopathic Medicine from New England College of Osteopathic Medicine, completed his Physical Medicine and Rehabilitation residency at Emory University School of Medicine where he served as Chief Resident, and completed his fellowship in non-surgical Sports Medicine at Emory University, where he provided physician coverage for the Atlanta Dream WNBA team and Georgia Tech athletics. He serves as Assistant Clinical Professor for Orthopedics and Rehabilitation at Tufts University School of Medicine and the University of New England College of Osteopathic Medicine. He is a Board Member of the Interventional Orthobiologic Foundation (IOF) and a member of the American Academy of PM&R Biologics Working Group. He co-authored The Atlas of Interventional Orthopedics and has published over 75 peer-reviewed articles and book chapters on ultrasound-guided procedures and regenerative medicine. The practice also includes Dr. Erek Latzka, a dual board-certified physician in Physical Medicine and Rehabilitation and Sports Medicine with the RMSK credential in musculoskeletal sonography.
Address: 20 Walnut Street, Suite 14, Wellesley, MA 02481
Phone: (781) 591-7855
Website: https://bostonsportsandbiologics.com
Key Personnel:
- Dr. Walter Sussman, DO, MPH, Founder, dual board-certified in Physical Medicine and Rehabilitation and Sports Medicine, NEBCO DO, Emory PM&R residency (Chief Resident), Emory sports medicine fellowship, IOF Board Member, co-author of The Atlas of Interventional Orthopedics
- Dr. Erek Latzka, MD, RMSK, Physician, dual board-certified in Physical Medicine and Rehabilitation and Sports Medicine
Services Offered:
- Platelet-Rich Plasma (PRP) injections
- Regenerative cell injections
- Ultrasound-guided orthopedic procedures
- Tenex percutaneous tendon treatment
- Non-surgical musculoskeletal and sports medicine consultation
Conditions Treated: Knee and hip arthritis, shoulder and rotator cuff conditions, tennis and golfer’s elbow, calcific tendonitis, Achilles tendinopathy, plantar fasciitis, hip bursitis, patellar tendinopathy, sports injuries, concussion management
3. Mass General Brigham Regenerative Sports Medicine
The Mass General Brigham Regenerative Sports Medicine Program is an academic sports medicine practice at the Spaulding Newton-Wellesley Rehabilitation Center, directed by Dr. Joanne Borg Stein, one of the most clinically and academically accomplished physiatrists in the United States. Dr. Borg Stein graduated from Albert Einstein College of Medicine and is an Associate Professor at Harvard Medical School, where she serves as Associate Chair and Chief of the Division of Sports and Musculoskeletal Rehabilitation at Spaulding Rehabilitation. She holds triple board certification in Physical Medicine and Rehabilitation, Pain Medicine, and Sports Medicine. She has directed the Regenerative Medicine Program at Mass General Brigham Sports Medicine for over 20 years and has been a leading clinical researcher in platelet-rich plasma therapy for degenerative disease and sports injury, with clinical specialties including diagnostic and interventional musculoskeletal ultrasound, prolotherapy, and cell therapies. She also serves as Medical Director of the Spaulding Wellesley Center and Team Physician for Wellesley College.
Address: 65 Walnut Street, Suite 260, Wellesley, MA 02481
Phone: (781) 431-9144
Key Personnel:
- Dr. Joanne Borg Stein, MD, Director, triple board-certified in Physical Medicine and Rehabilitation, Pain Medicine, and Sports Medicine, Albert Einstein College of Medicine MD, Associate Professor and Chief of Sports and Musculoskeletal Rehabilitation at Harvard Medical School/Spaulding, Director of MGB Regenerative Sports Medicine Program
Services Offered:
- Bone marrow aspirate concentrate (BMAC) therapy
- Platelet-Rich Plasma (PRP) therapy
- Prolotherapy
- Musculoskeletal ultrasound-guided procedures
- Comprehensive sports medicine and rehabilitation
Conditions Treated: Knee and hip arthritis, tendon and ligament injuries, sports injuries, shoulder and rotator cuff conditions, degenerative joint conditions, women’s musculoskeletal conditions
4. Boston Applied Biologics
Boston Applied Biologics is a Framingham practice led by Dr. Janet D. Pearl, a triple board-certified physician who brings one of the most academically distinguished backgrounds in the Boston regenerative medicine market. Dr. Pearl received her undergraduate degree from Harvard College, her Master of Science from the London School of Hygiene and Tropical Medicine, and her medical degree from Columbia College of Physicians and Surgeons. She completed her internship in internal medicine at New England Deaconess Hospital, her anesthesiology residency at Massachusetts General Hospital, and a fellowship in Pain Management at Brigham and Women’s Hospital. She is also board-certified in Regenerative Medicine and serves as Medical Director of Complete Spine and Pain Care in Framingham. The practice uses autologous bone marrow aspirate concentrate and platelet-rich plasma delivered under ultrasound or fluoroscopic guidance as FDA-consistent alternatives to surgery for hip, knee, ankle, shoulder, elbow, spine, and tendon conditions.
Address: 600 Worcester Road, Suite 301, Framingham, MA 01702
Phone: (508) 231-5700
Website: https://www.bostonbiologic.com
Key Personnel:
- Dr. Janet D. Pearl, MD, MSc, Medical Director, triple board-certified including in Regenerative Medicine, Harvard College AB, London School of Hygiene MSc, Columbia College of Physicians and Surgeons MD, MGH anesthesiology residency, Brigham and Women’s Pain Management fellowship
Services Offered:
- Bone marrow aspirate concentrate (BMAC) therapy
- Platelet-Rich Plasma (PRP) therapy
- Ultrasound and fluoroscopy-guided injection procedures
- Non-surgical regenerative treatment for joint and tendon conditions
Conditions Treated: Hip, knee, ankle, shoulder, elbow, spine, and tendon conditions; joint arthritis, soft tissue injuries, degenerative musculoskeletal conditions
5. Boston Medical Center Orthopedics
Boston Medical Center Orthopedics is an academic orthopedic practice at Boston Medical Center led by Dr. Xinning “Tiger” Li, a board-certified orthopedic surgeon and Professor of Orthopedic Surgery at Boston University Chobanian and Avedisian School of Medicine. Dr. Li received his medical degree from the University of Virginia School of Medicine, completed his sports medicine fellowship at the Hospital for Special Surgery in New York (the nation’s top-ranked orthopedic hospital), where he served as assistant team physician for the New York Mets, and then completed a fellowship in Shoulder and Elbow Surgery at Harvard Medical School through Massachusetts General Hospital and Brigham and Women’s Hospital. He also completed an additional research fellowship in Tissue Engineering. He holds the FAOA and FAAOS designations and serves as Team Physician for Boston University Athletics. The practice offers autologous biologic therapies including stem cell treatment and PRP for degenerative conditions of the shoulder, knee, hip, spine, and soft tissue.
Address: 725 Albany Street, 4th Floor, Boston, MA 02118
Phone: (617) 638-5633
Website: https://www.tigerortho.com
Key Personnel:
- Dr. Xinning Li, MD, FAOA, FAAOS, Lead Physician, board-certified orthopedic surgeon, Professor of Orthopedic Surgery at Boston University, University of Virginia MD, Hospital for Special Surgery Sports Medicine fellowship, Harvard Medical School Shoulder and Elbow fellowship, Team Physician for Boston University Athletics
Services Offered:
- Stem cell therapy for joint and soft tissue conditions
- Platelet-Rich Plasma (PRP) therapy
- Orthobiologic injections
- Orthopedic surgery and arthroscopy (when indicated)
- Sports medicine consultation
Conditions Treated: Shoulder and rotator cuff conditions, knee injuries and arthritis, hip conditions, spine conditions, sports injuries, ligament and tendon tears, degenerative joint disease
About This Directory
This listing is part of a national regenerative medicine directory covering major metropolitan areas across the United States. Clinics included in this directory are real, operating practices with verified addresses and publicly available contact information. Inclusion does not imply endorsement, certification, or quality rating. Patients should independently verify provider credentials, treatment protocols, and regulatory compliance before pursuing any regenerative medicine treatment.
Many regenerative medicine treatments, including stem cell therapy and PRP, are considered investigational by the FDA for most orthopedic and musculoskeletal applications. Insurance coverage for these treatments is generally not available. Patients are encouraged to discuss all treatment options, risks, benefits, and costs with their healthcare provider before making any decisions.
Last updated: March 2026