Stem Cell Therapy and Regenerative Medicine Clinics in Miami, FL

Two Miami physicians on this list read the rules on donor cells in opposite ways, and a patient should see both statements. Dr. Alicia Carter’s site says umbilical cord and amniotic products “CANNOT be used for orthopedic conditions under current FDA guidelines.” Karli Health’s site says Florida’s 2025 law “expressly authorizes” physicians to provide donor-derived stem cell therapies for orthopedic, wound care and pain uses. Both can be describing a real rule, because one is federal and the other is state. The federal agency has approved no such product for a joint. A third practice offers PRP within general orthopedics.

Miami Practices Compared

Clinic	Where	Physician named	What its site says it uses	Price posted
Regenerative Medicine and Orthopedics (Alicia R. Carter, MD)	Biscayne Blvd	Alicia R. Carter, MD	Own marrow or fat, PRP; no donor products	Not posted
Karli Health Institute	S. Miami Ave	David Karli, MD	PRP, marrow concentrate, donor cord cells, MUSE cells, exosomes	Not posted
Legacy Orthopaedics	SW 62nd Ave	Thomas D. Riley IV, MD	PRP, other regenerative injections	Not posted

Regenerative Medicine and Orthopedics (Alicia R. Carter, MD)

Dr. Carter is a physical medicine and sports physician. Her site says marrow from the pelvic bone or a small amount of abdominal fat are the usual sources, that this grafting “is still considered experimental in orthopedics and sports medicine,” and that insurers “almost never pay.”

• Address: 4770 Biscayne Blvd., Suite 1100, Miami, FL 33137
• Phone: 305-680-3527
• Website: https://miamispineandsportsdoctor.com/
• Physicians: Alicia R. Carter, MD, FAAPMR
• What the site lists: Bone marrow and fat-derived grafts, PRP, spine injections
• Insurance and price: The site says PRP and stem cell procedures are not covered by insurance and that she is out of network with all insurers; it offers a free estimate if you text your MRI report
• Ask: What would you try before a cell procedure, and what do you measure to decide it worked?

Karli Health Institute

Dr. Karli’s practice lists PRP, bone marrow concentrate, umbilical cord-derived cell therapy, MUSE cell therapy and exosome therapy, or combinations. The site displays the Florida notice. It also describes longevity services. Ask which item is recommended for your joint and why.

• Address: 3683 S Miami Ave, Suite 460, Miami, FL 33133
• Phone: (305) 459-3377
• Website: https://www.karlihealth.com/
• Physicians: David Karli, MD, MBA
• What the site lists: PRP, marrow concentrate, donor cord cells, MUSE cells, exosomes
• Insurance and price: The site has an insurance explanation; fees are not posted on the pages read
• Ask: Under Florida’s law, which accredited facility supplies the cells, and may I see the post-thaw viability report for my lot?

Legacy Orthopaedics

This is a conventional board-certified orthopedic practice whose PRP page says PRP and “other regenerative injection treatments” boost healing, and which says it accepts most major insurance plans. It suits a patient starting with a diagnosis rather than a product.

• Address: 7000 SW 62nd Ave., Suite 330, Miami, FL 33143
• Phone: 786-238-7402
• Website: https://www.legacyorthopaedics.net/
• Physicians: Thomas D. Riley, IV, MD
• What the site lists: PRP, regenerative injections, orthopedic surgery
• Insurance and price: Most major plans accepted for orthopedic care; PRP fee not posted on the pages read
• Ask: Is PRP billed to my plan, and which other regenerative injections do you offer here?

Florida’s Rule and FDA’s Rule Are Not the Same Thing

Under section 458.3245, Florida Statutes, a Florida physician may perform stem cell therapy that FDA has not approved in orthopedics, wound care or pain management, within that physician’s practice, under source and consent rules. Every advertisement must carry a notice that begins “THIS NOTICE MUST BE PROVIDED TO YOU UNDER FLORIDA LAW.” That notice itself says the therapies have not yet been approved by FDA. Look for it on a clinic’s site and ads; its absence is a question to ask, since the statute has exceptions.

State permission does not change what FDA says. FDA’s consumer notice lists cord blood, amniotic fluid, Wharton’s jelly and exosomes among unapproved products and warns that being charged for them outside a clinical trial means “you are likely being deceived and offered a product illegally.” FDA says products regulated as biologics require an approved license to be marketed lawfully, and that no exosome product is approved. We do not classify any individual product here. A patient buying a donor product in Florida is relying on a state permission that FDA has not matched, and should get the product’s name and paperwork in writing.

Trial and Guideline Results

In a phase 3 trial of 480 randomized knee patients (440 analyzed), marrow concentrate, fat-derived cells and umbilical cord tissue cells were no better than cortisone at a year. The American College of Rheumatology’s 2026 recommendations strongly recommend against PRP and stem cell injections in the knee and hip. MUSE cells and exosomes were not tested in that trial, so ask what controlled evidence exists for them.

Practical Steps

Check licenses with the Florida Board of Medicine (MDs) or Board of Osteopathic Medicine (DOs). Ask for a written total, since no practice here posts one on the pages read. Patients elsewhere in the state can compare the lists for Tampa and Jacksonville.

Details are from each clinic’s website as read in November 2026 and could change, so confirm them. We are not endorsing or ranking anyone here, and this is not medical advice. FDA has received reports of blindness, tumors and infections from unapproved regenerative products.